Harinder Singh, PhD

Louis Block Professor of Molecular Genetics and Cell Biology

Chairman, Committee on Immunology

Investigator, Howard Hughes Medical Institute

Dr. Harinder Singh is the Louis Block Professor of Molecular Genetics & Cell Biology at the University of Chicago, an investigator with the Howard Hughes Medical Institute, and Chair of the Committee on Immunology. Dr. Singh earned his PhD in Biochemistry and Molecular Biology from Northwestern University. After postdoctoral training at the Massachusetts Institute of Technology as a Jane Coffin Childs Fellow, he joined the University of Chicago faculty in 1989.

Singh is an expert on regulatory molecules that enable a self-renewing pluripotent hematopoietic stem cell to generate various cells of the immune system. His laboratory focuses on genetic and molecular analyses of transcription factors that regulate the development and differentiation of immune cells. His group has identified key regulatory proteins that control the generation of both innate and adaptive cells of the immune system. These proteins can be thought of as genetic switches and are components of intricate control circuits that turn on and off large sets of genes enabling the generation of specialized cell types. Dr. Singh plans to manipulate these control circuits to engineer stem cells to efficiently adopt particular immune cell fates facilitating their use for therapeutic purposes.

The author of over 50 research papers, review articles, and book chapters, Dr. Singh has served as editor of Molecular and Cellular Biology from 1997-2007. He has given invited research presentations at scientific meetings throughout the United States, Europe, and Asia. He has been a member of the Board of Scientific Counselors for the National Cancer Institute and is currently serving as an advisor to the California Institute for Regenerative Medicine.

Selected Publications from 2010 – 2011

  • Sciammas R, Li Y, Warmflash A, Song Y, Dinner AR, Singh H. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol 7:495, 2011.
  • Mewborn SK, Puckelwartz MJ, Abuisneineh F, Fahrenbach JP, Zhang Y, MacLeod H, Dellefave L, Pytel P, Selig S, Labno CM, Reddy K, Singh H, McNally E. Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation. PLoS One 5:e14342, 2010.