JohnCunningham

John Cunningham, MD

Professor of Pediatrics and Stem Cell Research Chief, Section of Pediatric Hematology/Oncology

Dr. Cunningham is an internationally-renowned expert in the treatment and research of childhood cancers and blood diseases. He has particular expertise in treating hemoglobinopathies, which are disorders that affect red blood cells, such as sickle cell disease and thalassemia. He is a recognized leader in the field of pediatric stem cell transplantation, and has developed novel uses for this life-saving treatment.

An active researcher, Dr. Cunningham is studying the biology and therapy of hemoglobinopathies, the development of clinical trials for the treatment of genetic diseases, and transcriptional mechanisms operative during the development of vertebrate organisms. Over his distinguished career, Dr. Cunningham’s research has received support from the National Heart, Lung, and Blood Institute, the American Society of Hematology, and other prominent scientific organizations. He is vice chair of the American Cancer Society Molecular Genetics and Oncogenes Study Section.

Dr. Cunningham is an accomplished author and has published more than 50 scientific articles, as well as several book chapters and invited reviews. He has served on the editorial board of the Journal of Biological Chemistry, and is a reviewer for Blood, Molecular and Cellular Biology, Cancer Research, and Genomics. A popular speaker, Dr. Cunningham has lectured at universities and scientific meetings around the world. Before joining the University of Chicago as Chief of the Section of Pediatric Hematology/Oncology, Dr. Cunningham was a leader in the Division of Experimental Hematology and Bone Marrow Transplantation at St. Jude Children’s Research Hospital in Memphis, Tennessee.

Selected Publications from 2010 – 2011

  • Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP. The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy Sci Signal 4:ra46, 2011.
  • Zheng Y, Zhao YD, Gibbons M, Abramova T, Chu PY, Ash JD, Cunningham JM, Skapek SX. Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK. J Biol Chem 285:35654-3564, 2010.

Reviews/Editorials

  • Godley LA, Cunningham J, Dolan ME, Huang RS, Gurbuxani S, McNerney ME, Larson RA, Leong H, Lussier Y, Onel K, Odenike O, Stock W, White KP, Le Beau MM. An integrated genomic approach to the assessment and treatment of acute myeloid leukemia. Semin Oncol 38:215-224, 2011.